What does Antisecretory mean:
“Antisecretory refers to compounds used to reduce the secretion of fluids in the body, particularly in the context of treating conditions like peptic ulcers and GERD.”
(source: sciencedirect.com)
What are gastric antisecretory drugs:
“Gastric antisecretory drugs, mainly including histamine-2 receptor antagonists (H2RAs) and proton pump inhibitors (PPIs), are administered in pediatric patients with different gastrointestinal conditions (nausea, vomiting, abdominal pain, and hematemesis) [1], gastroesophageal reflux disease (GERD)”
(source: ncbi.nlm.nih.gov)
“PPIs (omeprazole, esomeprazole, lansoprazole, pantoprazole, and rabeprazole) are among the most prescribed drugs worldwide.”
(source: ncbi.nlm.nih.gov)
The use of PPIs is indicated as follows:
(source: Dig Dis (2020) 38 (2): 104–111.)
“Short-term PPI therapy appropriate
– Healing of erosive esophagitis (Los Angeles grade A and B)
– *Helicobacter pylori* eradication (in combination with antibiotics)
– Functional dyspepsia
– Peptic ulcer disease
– Acute upper gastrointestinal bleeding
– Stress-ulcer prophylaxis in high-risk patients
– Eosinophilic esophagitis
Long-term PPI appropriate
– Barrett’s esophagus
– Severe erosive esophagitis (Los Angeles grades C and D)
– Zollinger-Ellison syndrome
– Idiopathic peptic ulcer disease
– Gastroprotection in high-risk patients (long-term nonselective NSAID-users)
– Anti-platelet therapy in patients at high risk for upper GI complications
– PPI-responsive Eosinophilic esophagitis
PPI use – no benefit
– Corticosteroid treatment (unless used in combination with NSAIDs)
– Acute pancreatitis (no benefit from acid inhibition)
– Hypertensive gastropathy (no need for acid suppression)
– Chronic pancreatitis (standard dose of PPI only in patients with steatorrhea, refractory to enzyme replacement treatment)
– Stress ulcer prophylaxis in noncritically ill hospitalized patients and low risk for upper GI complications
– Anticoagulant therapy (no need for gastroprotection unless used in combination with NSAIDs)”